Please use this identifier to cite or link to this item: http://115.74.233.203:81/tailieuso/handle/123456789/732
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dc.contributor.authorNguyen, Ngoc Chuong-
dc.contributor.authorTran, Cong Luan-
dc.contributor.authorManh, Hung Tran-
dc.date.accessioned2021-02-24T07:50:57Z-
dc.date.available2021-02-24T07:50:57Z-
dc.date.issued2021-
dc.identifier.citationChuong, N. N. ., Luan, T. C. ., & Tran, M. H. . (2021). Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activity. Current Advances in Chemistry and Biochemistry Vol. 1, 85–92. https://doi.org/10.9734/bpi/cacb/v1/7263Dvi
dc.identifier.issn978-93-90516-18-6-
dc.identifier.urihttp://115.74.233.203:81/tailieuso/handle/123456789/732-
dc.description.abstractA series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8?-hydrophlemariurine B (5) and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 µg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors. This is the first report on the alkaloid constituents of H. squarrosa from Vietnam and the potential cholinesterase inhibitory activity of these compounds might suggest new sources of anti-Alzheimer disease agents.vi
dc.language.isoen_USvi
dc.publisherCurrent Advances in Chemistry and Biochemistry Vol. 1vi
dc.subjectHuperzia squarrosavi
dc.subjectLycopodiaceaevi
dc.titleLycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis and Their Anti-cholinesterase Activityvi
dc.typeWorking Papervi
Appears in Collections:ĐTNCKH-Khoa Dược - Điều dưỡng

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